| Player | Date of Birth | Games | Subs | Goals |
| Eric Sabin | 22/01/1975 | 34 | 1 | 9 |
| Abdou Sall | 01/11/1980 | 0 | 2 | 0 |
| Mike Salmon | 14/07/1964 | 1 | 0 | 0 |
| Kevin Sandwith | 30/04/1978 | 30 | 10 | 3 |
| Djoumin Sangare | 16/12/1983 | 2 | 2 | 0 |
| Georges Santos | 15/08/1970 | 5 | 0 | 0 |
| Reneil `Ricky` Sappleton | 08/12/1989 | 2 | 3 | 1 |
| Carl Saunders | 26/11/1964 | 2 | 3 | 0 |
| Dean Saunders | 21/06/1964 | 70 | 3 | 33 |
| David Savage | 30/07/1973 | 95 | 0 | 5 |
| Andy Scott | 02/08/1972 | 80 | 20 | 25 |
| David Scott | 06/06/1918 | 32 | 0 | 0 |
| Jason Seacole | 11/04/1960 | 113 | 21 | 26 |
| Steve Seddon | 25/12/1997 | 51 | 7 | 4 |
| Peter Selby | 2 | 0 | 0 | |
| Ryan Semple | 04/07/1985 | 0 | 1 | 0 |
| Liam Sercombe | 25/04/1990 | 86 | 15 | 22 |
| Pete Sharman | 25 | 0 | 0 | |
| Paul Shaw | 04/09/1973 | 9 | 0 | 2 |
| Scott Shearer | 15/02/1981 | 3 | 0 | 0 |
| Gary Shelton | 21/03/1958 | 73 | 6 | 3 |
| Jon Shepheard | 31/03/1981 | 10 | 1 | 1 |
| John Shepherd | 20/09/1945 | 14 | 2 | 1 |
| Jimmy Sheridan | 37 | 0 | 4 | |
| Brian Sherratt | 29/03/1944 | 52 | 0 | 0 |
| Jimmy Shields | 26/09/1931 | 5 | 0 | 1 |
| Keith Shipperley | 10 | 0 | 3 | |
| Olamide Shodipo | 05/07/1997 | 28 | 18 | 13 |
| Malcolm Shotton | 16/02/1957 | 336 | 2 | 15 |
| John Shuker | 08/05/1942 | 529 | 5 | 47 |
| Tim Sills | 10/09/1979 | 9 | 4 | 1 |
| Billy Simpson | 07/02/1932 | 11 | 0 | 3 |
| George Simpson | 03/12/1933 | 3 | 0 | 0 |
| Paul Simpson | 26/07/1966 | 162 | 6 | 50 |
| John Sims | 14/08/1952 | 6 | 1 | 1 |
| Jerome Sinclair | 20/09/1996 | 10 | 6 | 4 |
| Joe Skarz | 13/07/1989 | 105 | 2 | 0 |
| Ken Skeen | 20/03/1942 | 248 | 22 | 40 |
| John Skull | 25/08/1932 | 33 | 0 | 14 |
| Jamie Slabber | 31/12/1984 | 2 | 1 | 0 |
| Neil Slatter | 30/05/1964 | 112 | 3 | 9 |
| David Sloan | 28/10/1941 | 189 | 11 | 33 |
| Sam Slocombe | 05/06/1988 | 28 | 0 | 0 |
| Deane Smalley | 07/09/1988 | 51 | 41 | 16 |
| Gary Smart | 29/04/1964 | 195 | 9 | 0 |
| Jimmy Smillie | 75 | 0 | 29 | |
| Andy Smith | 70 | 0 | 0 | |
| Barry Smith | 15/03/1934 | 14 | 0 | 5 |
| Charlie Smith | 1 | 0 | 0 | |
| Dave Smith | 26/12/1970 | 232 | 7 | 3 |
| Jay Smith | 25/09/1981 | 5 | 1 | 0 |
| Jim Smith | 142 | 0 | 22 | |
| Jonte Smith | 10/07/1994 | 0 | 1 | 0 |
| Ken Smith | 21/05/1932 | 58 | 0 | 32 |
| Roy Smith | 26 | 0 | 0 | |
| Sam Smith | 08/03/1998 | 11 | 12 | 3 |
| Tyler Smith | 04/12/1998 | 2 | 6 | 0 |
| Ashley Smith-Brown | 31/03/1996 | 9 | 0 | 0 |
| Tim Smithers | 22/01/1956 | 118 | 6 | 7 |
| Rodney Smithson | 09/10/1943 | 174 | 6 | 6 |
| Oisin Smyth | 05/05/2000 | 2 | 6 | 0 |
| Onome Sodje | 17/07/1988 | 2 | 3 | 1 |
| Fabio Sole | 0 | 1 | 0 | |
| Slavi Spasov | 31/12/2001 | 0 | 8 | 1 |
| Tony Spearing | 07/10/1964 | 5 | 0 | 0 |
| Ron Spelman | 22/05/1938 | 18 | 1 | 2 |
| Kieron St Aimee | 04/05/1989 | 3 | 0 | 0 |
| Ian Stables | 6 | 0 | 0 | |
| Michael Standing | 20/03/1981 | 3 | 4 | 0 |
| Sid Stanton | 16/06/1923 | 51 | 0 | 1 |
| Ronnie Steel | 03/06/1929 | 131 | 0 | 32 |
| Lee Steele | 07/12/1973 | 6 | 21 | 4 |
| Mark Stein | 28/01/1966 | 81 | 11 | 18 |
| Alf Stephens | 7 | 0 | 1 | |
| Jack Stevens | 02/08/1997 | 73 | 1 | 0 |
| Mark Stevens | 03/12/1977 | 0 | 1 | 0 |
| Jude Stirling | 29/06/1982 | 9 | 5 | 0 |
| Sam Stockley | 05/09/1977 | 42 | 2 | 0 |
| Ian Stott | 17/10/1955 | 30 | 0 | 3 |
| Alan Styles | 5 | 0 | 0 | |
| Jimmy Sweetzer | 08/01/1960 | 1 | 8 | 2 |
| Mark Sykes | 04/08/1997 | 107 | 30 | 12 |
Data correct to July 2023
