Oxford United are back in Sheffield for the rearranged fixture at Brammall Lane.
The original tie was scheduled for 4 January, but it was called off on the day by the referee due to a frozen pitch.
United will be hoping to bounce back from the weekend's defeat, and Matt Bloomfield has made five changes.
Will Vaulks, Michal Helik, Przemylsaw Placheta and Will Lankshear all come in, while there is a debut for Christ Makosso. On the bench, Jin Woo Jeon returns and could make his debut.
Kick-off in Sheffield is at 7:45pm. You can keep up to date with all the action on the Club's Official Instagram and X accounts.
Oxford United: Cumming, Long, Brown, Vaulks, Helik, Placheta, Brannagan, Spencer, Lankshear, Makosso, Peart-Harris
Subs: Ingram, Konak, Harris, Romeny, Mills, Leigh, Dembele, Davies, Jin Woo